Tag

Mood

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Two dark armchairs facing each other in front of a window with closed blinds in a dim room

Psilocybin beat placebo in the first NHS-funded trial

King's College London randomized 60 people with treatment-resistant depression to a single 25mg dose or a true placebo, both with psychological support. Depression scores fell further on psilocybin. The trial was built to test feasibility.

Aug 9, 2026

A middle-aged man sitting on a pale sofa at home, holding a phone to his ear and gesturing

News

Self-guided therapy beat clinician sessions for chronic pain

A JAMA trial randomized 764 veterans with chronic musculoskeletal pain to a self-directed program with recorded coach feedback or to therapy with a clinician. The self-directed group did better at four months and at twelve.

Aug 8, 2026

Grey capsules spilled from a clear bottle onto a yellow background

verdict

NAC: uses, evidence, dosing and safety

NAC is a hospital antidote sold as a supplement, and the two are not the same claim. It saves lives in paracetamol overdose. For almost everything it is marketed for, the evidence is thin or uncertain.

Aug 5, 2026

An older woman wrapped in a striped shirt looking away in a brick-walled room

News

Swinging mood predicted dementia better than low mood

Following 11,951 older adults for up to 19 years, researchers found that fluctuating depressive symptoms predicted later cognitive impairment better than how depressed someone was at any single visit.

Aug 4, 2026